Switch #: SWTI000378

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y1139 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-2 (ERBB2) induces binding to the Growth factor receptor-bound protein 7 (GRB7) protein.

Participants:
(1) Receptor tyrosine-protein kinase erbB-2 (ERBB2)
(2) Growth factor receptor-bound protein 7 (GRB7)

(1) Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2.
Ivancic et al. J. Biomol. NMR (2003)

Other switches involving participants
Receptor tyrosine-protein kinase erbB-2 (ERBB2) - 5 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IC - 12 more (view)