Switch #: SWTI000384

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y791 in the SH2-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the SHC-transforming protein 1 (SHC1) protein.

Participants:
(1) High affinity nerve growth factor receptor (NTRK1)
(2) SHC-transforming protein 1 (SHC1)

(1) Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor.
Mardy et al. Hum. Mol. Genet. (2001)

Other switches involving participants
SHC-transforming protein 1 (SHC1) - 15 more (view)
High affinity nerve growth factor receptor (NTRK1) - 2 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIB - 12 more (view)