Switch #: SWTI000385

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y791 in the SH2-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the Megakaryocyte-associated tyrosine-protein kinase (MATK) protein.

Participants:
(1) High affinity nerve growth factor receptor (NTRK1)
(2) Megakaryocyte-associated tyrosine-protein kinase (MATK)

(1) The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells.
Yamashita et al. J. Biol. Chem. (1999)

Other switches involving participants
High affinity nerve growth factor receptor (NTRK1) - 2 more (view)
Megakaryocyte-associated tyrosine-protein kinase (MATK) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IB - 13 more (view)