Switch #: SWTI000386

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y981 in the SH2-binding motif of Proto-oncogene tyrosine-protein kinase receptor Ret (RET) induces binding to the SH2B adapter protein 1 (SH2B1) protein.

Participants:
(1) Proto-oncogene tyrosine-protein kinase receptor Ret (RET)
(2) SH2B adapter protein 1 (SH2B1)

(1) SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signaling.
Donatello et al. Oncogene (2007)

Other switches involving participants
SH2B adapter protein 1 (SH2B1) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIB - 12 more (view)