Switch #: SWTI000387

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y1356 in the SH2-binding motif of Hepatocyte growth factor receptor (MET) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.

Participants:
(1) Hepatocyte growth factor receptor (MET)
(2) Growth factor receptor-bound protein 2 (GRB2)

(1) Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a.
Schiering et al. Proc. Natl. Acad. Sci. U.S.A. (2003)

Other switches involving participants
Growth factor receptor-bound protein 2 (GRB2) - 12 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IC - 12 more (view)