Switch #: SWTI000388

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y751 in the SH2-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) induces binding to the Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) protein.

Participants:
(1) Platelet-derived growth factor receptor beta (PDGFRB)
(2) Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

(1) NMR trial models: experiences with the colicin immunity protein Im7 and the p85alpha C-terminal SH2-peptide complex.
Pauptit et al. Acta Crystallogr. D Biol. Crystallogr. (2001)

Other switches involving participants
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) - 6 more (view)
Platelet-derived growth factor receptor beta (PDGFRB) - 2 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIA - 12 more (view)