Switch #: SWTI000389

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y1021 in the SH2-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.

Participants:
(1) Platelet-derived growth factor receptor beta (PDGFRB)
(2) 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)

(1) Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide.
Pascal et al. Cell (1994)

Other switches involving participants
Platelet-derived growth factor receptor beta (PDGFRB) - 2 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIA - 12 more (view)