Switch #: SWTI000390

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y595 in the SH2-binding motif of Growth hormone receptor (GHR) induces binding to the Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) protein.

Participants:
(1) Growth hormone receptor (GHR)
(2) Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)

(1) Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B.
Stofega et al. Mol. Endocrinol. (2000)

Other switches involving participants
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) - 9 more (view)
Growth hormone receptor (GHR) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIA - 12 more (view)