Switch #: SWTI000391

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y436 in the SH2-binding motif of Growth hormone receptor (GHR) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.

Participants:
(1) Growth hormone receptor (GHR)
(2) Signal transducer and activator of transcription 5B (STAT5B)

(1) Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase.
Yi et al. Mol. Endocrinol. (1996)

Other switches involving participants
Growth hormone receptor (GHR) - 1 more (view)
Signal transducer and activator of transcription 5B (STAT5B) - 5 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_III - 15 more (view)