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Switch #:
SWTI000392
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y418 in the SH2-binding motif of Interleukin-2 receptor subunit beta (IL2RB) induces binding to the Tyrosine-protein kinase Lck (LCK) protein.

Participants:
(1) Interleukin-2 receptor subunit beta (IL2RB)
(2) Tyrosine-protein kinase Lck (LCK)

Interactions
Interaction #1 IL2RB - LCK

Interfaces
(1) ELM:LIG_SH2_IA motif (409QPLSGEDDAYCTFPSRDDLL428) in Interleukin-2 receptor subunit beta (IL2RB)
(2) SH2 domain (127-209) in Tyrosine-protein kinase Lck (LCK)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y418 on Interleukin-2 receptor subunit beta (IL2RB)) of the Interleukin-2 receptor subunit beta (IL2RB) LIG_SH2_IA motif - Tyrosine-protein kinase Lck (LCK) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y418 : Tyrosine-protein kinase Lck (LCK).

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane
References

(1) Biochemical analysis of interleukin-2 receptor beta chain phosphorylation by p56(lck).
Delespine-Carmagnat et al. FEBS Lett. (1999)

See also

Other switches involving participants
Interleukin-2 receptor subunit beta (IL2RB) - 4 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IA - 16 more (view)


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