Switch #: SWTI000393

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y536 in the SH2-binding motif of Interleukin-2 receptor subunit beta (IL2RB) induces binding to the Signal transducer and activator of transcription 5A (STAT5A) protein.

Participants:
(1) Interleukin-2 receptor subunit beta (IL2RB)
(2) Signal transducer and activator of transcription 5A (STAT5A)

(1) Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain.
Delespine-Carmagnat et al. Eur. J. Immunol. (2000)

Other switches involving participants
Interleukin-2 receptor subunit beta (IL2RB) - 4 more (view)
Signal transducer and activator of transcription 5A (STAT5A) - 3 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_III - 15 more (view)