Switch #: SWTI000394

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y364 in the SH2-binding motif of Interleukin-2 receptor subunit beta (IL2RB) induces binding to the SHC-transforming protein 1 (SHC1) protein.

Participants:
(1) Interleukin-2 receptor subunit beta (IL2RB)
(2) SHC-transforming protein 1 (SHC1)

(1) Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain.
Delespine-Carmagnat et al. Eur. J. Immunol. (2000)

Other switches involving participants
SHC-transforming protein 1 (SHC1) - 15 more (view)
Interleukin-2 receptor subunit beta (IL2RB) - 4 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIB - 12 more (view)