Switches.ELM

Switch #:

SWTI000396

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y457 in the SH2-binding motif of Interferon gamma receptor 1 (IFNGR1) induces binding to the Signal transducer and activator of transcription 1-alpha/beta (STAT1) protein.

Participants:
(1) Interferon gamma receptor 1 (IFNGR1)
(2) Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Interactions

Interaction #1 IFNGR1 - STAT1

Interfaces
(1) ELM:LIG_SH2_III motif (₄₅₇YDKPH₄₆₁) in Interferon gamma receptor 1 (IFNGR1)
(2) SH2 domain_(577-658) in Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y₄₅₇ on Interferon gamma receptor 1 (IFNGR1)) of the Interferon gamma receptor 1 (IFNGR1) LIG_SH2_III motif - Signal transducer and activator of transcription 1-alpha/beta (STAT1) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y₄₅₇ : Tyrosine-protein kinase JAK1 (JAK1).

Additional Information
Structural information: 1YVL

Context

Switch localisation
Curated: cytoplasmic side of plasma membrane

Switch pathways

References

(1) Structural bases of unphosphorylated STAT1 association and receptor binding.
Mao et al. Mol. Cell (2005)