About Help Definitions Submit Search Analyse Browse Home


Switch #:
SWTI000397
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y174 in the SH2-binding motif of Proto-oncogene vav (VAV1) induces binding to the SH2 domain-containing adapter protein B (SHB) protein.

Participants:
(1) Proto-oncogene vav (VAV1)
(2) SH2 domain-containing adapter protein B (SHB)

Interactions
Interaction #1 VAV1 - SHB

Interfaces
(1) ELM:LIG_SH2_IIB motif (165NEEAEGDEIYEDLMRS180) in Proto-oncogene vav (VAV1)
(2) SH2 domain (410-485) in SH2 domain-containing adapter protein B (SHB)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y174 on Proto-oncogene vav (VAV1)) of the Proto-oncogene vav (VAV1) LIG_SH2_IIB motif - SH2 domain-containing adapter protein B (SHB) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y174 : Tyrosine-protein kinase Lck (LCK).

Context
Switch localisation
Inferred: plasma membrane
References

(1) Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells.
Lindholm et al. Eur. J. Biochem. (2002)

See also

Other switches involving participants
SH2 domain-containing adapter protein B (SHB) - 3 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIB - 12 more (view)


Loading visualisation

           
Please send any suggestions/comments to: switches@elm.eu.org