Switch #: SWTI000398

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y720 in the SH2-binding motif of Platelet-derived growth factor receptor alpha (PDGFRA) induces binding to the SH2 domain-containing adapter protein F (SHF) protein.

Participants:
(1) Platelet-derived growth factor receptor alpha (PDGFRA)
(2) SH2 domain-containing adapter protein F (SHF)

(1) Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis.
Lindholm et al. Biochem. Biophys. Res. Commun. (2000)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIB - 12 more (view)