Switch #: SWTI000400

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y481 in the SH2-binding motif of Interferon alpha/beta receptor 1 (IFNAR1) induces binding to the Non-receptor tyrosine-protein kinase TYK2 (TYK2) protein.

Participants:
(1) Interferon alpha/beta receptor 1 (IFNAR1)
(2) Non-receptor tyrosine-protein kinase TYK2 (TYK2)

(1) Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.
Colamonici et al. Mol. Cell. Biol. (1994)

Other switches involving participants
Interferon alpha/beta receptor 1 (IFNAR1) - 1 more (view)
Non-receptor tyrosine-protein kinase TYK2 (TYK2) - 1 more (view)

Other switches involving interfaces
ELM:LIG_SH2_IE - 11 more (view)
IPR:IPR000980 - 9 more (view)