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Switch #:
SWTI000410
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y774 in the SH2-binding motif of E3 ubiquitin-protein ligase CBL (CBL) induces binding to the Adapter molecule crk (CRK) protein.

Participants:
(1) E3 ubiquitin-protein ligase CBL (CBL)
(2) Adapter molecule crk (CRK)

Interactions
Interaction #1 CBL - CRK

Interfaces
(1) ELM:LIG_SH2_IB motif (770EDDGYDVPKPP780) in E3 ubiquitin-protein ligase CBL (CBL)
(2) SH2 domain (13-104) in Adapter molecule crk (CRK)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y774 on E3 ubiquitin-protein ligase CBL (CBL)) of the E3 ubiquitin-protein ligase CBL (CBL) LIG_SH2_IB motif - Adapter molecule crk (CRK) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y774 : Tyrosine-protein kinase Yes (YES1), Tyrosine-protein kinase ABL1 (Abl1), Insulin receptor (Insr), Tyrosine-protein kinase Lck (LCK), Proto-oncogene tyrosine-protein kinase Src (SRC), Tyrosine-protein kinase Fyn (FYN), Tyrosine-protein kinase SYK (SYK).

Context
Switch localisation
Inferred: cytosol, nucleus, plasma membrane


Switch pathways
Inferred: Insulin signaling pathway, ErbB signaling pathway
References

(1) SH2 domains recognize contextual peptide sequence information to determine selectivity.
Liu et al. Mol. Cell Proteomics (2010)

See also

Other switches involving participants
E3 ubiquitin-protein ligase CBL (CBL) - 4 more (view)
Adapter molecule crk (CRK) - 7 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IB - 13 more (view)


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