Switch #: SWTI000411

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y575 in the SH2-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Signal transducer and activator of transcription 6 (STAT6) protein.

Participants:
(1) Interleukin-4 receptor subunit alpha (IL4R)
(2) Signal transducer and activator of transcription 6 (STAT6)

(1) IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells.
Rolling et al. FEBS Lett. (1996)

(2) The IL-4 receptor: signaling mechanisms and biologic functions.
Nelms et al. Annu. Rev. Immunol. (1999)

Other switches involving participants
Interleukin-4 receptor subunit alpha (IL4R) - 7 more (view)
Signal transducer and activator of transcription 6 (STAT6) - 5 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_III - 15 more (view)