Switch #: SWTI000416

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y713 in the SH2-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) protein.

Participants:
(1) Interleukin-4 receptor subunit alpha (IL4R)
(2) Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D)

(1) Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation.
Kashiwada et al. J. Immunol. (2001)

Other switches involving participants
Interleukin-4 receptor subunit alpha (IL4R) - 7 more (view)
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) - 4 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIB - 12 more (view)