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Switch #:
SWTI000417
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y602 in the SH2-binding motif of Ephrin type-A receptor 3 (EPHA3) induces binding to the Cytoplasmic protein NCK1 (NCK1) protein.

Participants:
(1) Ephrin type-A receptor 3 (EPHA3)
(2) Cytoplasmic protein NCK1 (NCK1)

Interactions
Interaction #1 EPHA3 - NCK1

Interfaces
(1) ELM:LIG_SH2_IA motif (597VDPHTYEDPT606) in Ephrin type-A receptor 3 (EPHA3)
(2) SH2 domain (282-356) in Cytoplasmic protein NCK1 (NCK1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y602 on Ephrin type-A receptor 3 (EPHA3)) of the Ephrin type-A receptor 3 (EPHA3) LIG_SH2_IA motif - Cytoplasmic protein NCK1 (NCK1) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y602 : Ephrin type-A receptor 3 (EPHA3).

Context

Switch pathways
Inferred: Axon guidance
References

(1) Regulation of process retraction and cell migration by EphA3 is mediated by the adaptor protein Nck1.
Hu et al. Biochemistry (2009)

See also

Other switches involving participants
Cytoplasmic protein NCK1 (NCK1) - 3 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IA - 16 more (view)


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