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Switch #:
SWTI000418
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.

Participants:
(1) SHC-transforming protein 1 (SHC1)
(2) Growth factor receptor-bound protein 2 (GRB2)

Interactions
Interaction #1 SHC1 - GRB2

Interfaces
(1) ELM:LIG_SH2_IC motif (423DDPSYVNVQNLDK435) in SHC-transforming protein 1 (SHC1)
(2) SH2 domain (60-135) in Growth factor receptor-bound protein 2 (GRB2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y427 on SHC-transforming protein 1 (SHC1)) of the SHC-transforming protein 1 (SHC1) LIG_SH2_IC motif - Growth factor receptor-bound protein 2 (GRB2) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y427 : Vascular endothelial growth factor receptor 3 (FLT4), Tyrosine-protein kinase SYK (SYK), Tyrosine-protein kinase ZAP-70 (ZAP70), Hepatocyte growth factor receptor (MET), Proto-oncogene tyrosine-protein kinase Src (SRC).

Additional Information
Structural information: 1QG1
Context
Switch localisation
Inferred: cytosol


Switch pathways
Inferred: Chemokine signaling pathway, Insulin signaling pathway, Neurotrophin signaling pathway, ErbB signaling pathway, Natural killer cell mediated cytotoxicity, Focal adhesion
References

(1) Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide.
Ogura et al. J. Mol. Biol. (1999)

See also

Other switches involving participants
SHC-transforming protein 1 (SHC1) - 15 more (view)
Growth factor receptor-bound protein 2 (GRB2) - 12 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IC - 12 more (view)


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