Interaction #1 SHC1 - GRB2
(1) ELM:LIG_SH2_IC motif (423DDPSYVNVQNLDK435) in SHC-transforming protein 1 (SHC1)
(2) SH2 domain (60-135) in Growth factor receptor-bound protein 2 (GRB2)
PTM-dependent Induction (Phosphorylation of Y427 on SHC-transforming protein 1 (SHC1)) of the SHC-transforming protein 1 (SHC1) LIG_SH2_IC motif - Growth factor receptor-bound protein 2 (GRB2) SH2 domain interaction
Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y427 : Vascular endothelial growth factor receptor 3 (FLT4), Tyrosine-protein kinase SYK (SYK), Tyrosine-protein kinase ZAP-70 (ZAP70), Hepatocyte growth factor receptor (MET), Proto-oncogene tyrosine-protein kinase Src (SRC).
Structural information: 1QG1
(1) Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide.
Other switches involving participants