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Switch #:
SWTI000419
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y76 in the SH2-binding motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces binding to the Tyrosine-protein kinase SYK (SYK) protein.

Participants:
(1) High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)
(2) Tyrosine-protein kinase SYK (SYK)

Interactions
Interaction #1 FCER1G - SYK

Interfaces
(1) ELM:LIG_SH2_IA motif (75TYETL79) in High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)
(2) SH2 domain (168-244) in Tyrosine-protein kinase SYK (SYK)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y76 on High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)) of the High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) LIG_SH2_IA motif - Tyrosine-protein kinase SYK (SYK) SH2 domain interaction

Additional Information
Structural information: 1CSY
Context
References

(1) Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.
Narula et al. Structure (1995)

See also

Other switches involving participants
Tyrosine-protein kinase SYK (SYK) - 4 more (view)
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IA - 16 more (view)




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