Switch #: SWTI000419

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y76 in the SH2-binding motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces binding to the Tyrosine-protein kinase SYK (SYK) protein.

Participants:
(1) High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)
(2) Tyrosine-protein kinase SYK (SYK)

(1) Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.
Narula et al. Structure (1995)

Other switches involving participants
Tyrosine-protein kinase SYK (SYK) - 4 more (view)
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IA - 16 more (view)