Switch #: SWTI000425

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y471 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) protein.

Participants:
(1) Fibroblast growth factor receptor substrate 2 (FRS2)
(2) Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)

(1) Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor.
Zhang et al. Mol. Endocrinol. (2008)

Other switches involving participants
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) - 9 more (view)
Fibroblast growth factor receptor substrate 2 (FRS2) - 5 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIA - 12 more (view)