Switches.ELM

Switch #:

SWTI000426

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y381 in the SH2-binding motif of Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) induces binding to the B-cell linker protein (BLNK) protein.

Participants:
(1) Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1)
(2) B-cell linker protein (BLNK)

Interactions

Interaction #1 MAP4K1 - BLNK

Interfaces
(1) ELM:LIG_SH2_IIB motif (₃₇₂QLSESSDDDYDDVDIPTPAE₃₉₁) in Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1)
(2) SH2 domain_(346-429) in B-cell linker protein (BLNK)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y₃₈₁ on Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1)) of the Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) LIG_SH2_IIB motif - B-cell linker protein (BLNK) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y₃₈₁ : Tyrosine-protein kinase SYK (SYK).

References

(1) Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes.
Sauer et al. J. Biol. Chem. (2001)