Switch #: SWTI000427

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y752 in the SH2-binding motif of Granulocyte colony-stimulating factor receptor (CSF3R) induces binding to the Suppressor of cytokine signaling 3 (SOCS3) protein.

Participants:
(1) Granulocyte colony-stimulating factor receptor (CSF3R)
(2) Suppressor of cytokine signaling 3 (SOCS3)

(1) Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction.
Hörtner et al. J. Immunol. (2002)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIA - 12 more (view)