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Switch #:
SWTI000427
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y752 in the SH2-binding motif of Granulocyte colony-stimulating factor receptor (CSF3R) induces binding to the Suppressor of cytokine signaling 3 (SOCS3) protein.

Participants:
(1) Granulocyte colony-stimulating factor receptor (CSF3R)
(2) Suppressor of cytokine signaling 3 (SOCS3)

Interactions
Interaction #1 CSF3R - SOCS3

Interfaces
(1) ELM:LIG_SH2_IIA motif (747SDQVLYGQLLGS758) in Granulocyte colony-stimulating factor receptor (CSF3R)
(2) SH2 domain (46-127) in Suppressor of cytokine signaling 3 (SOCS3)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y752 on Granulocyte colony-stimulating factor receptor (CSF3R)) of the Granulocyte colony-stimulating factor receptor (CSF3R) LIG_SH2_IIA motif - Suppressor of cytokine signaling 3 (SOCS3) SH2 domain interaction

Context
References

(1) Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction.
Hörtner et al. J. Immunol. (2002)

See also

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIA - 12 more (view)




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