Switch #: SWTI000428

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y203 in the SH2-binding motif of Docking protein 1 (DOK1) induces binding to the Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) protein.

Participants:
(1) Docking protein 1 (DOK1)
(2) Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D)

(1) The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells.
Dunant et al. Cell. Signal. (2000)

Other switches involving participants
Docking protein 1 (DOK1) - 4 more (view)
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) - 4 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIB - 12 more (view)