About Help Definitions Submit Search Analyse Browse Home


Switch #:
SWTI000429
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y449 in the SH2-binding motif of Docking protein 1 (DOK1) induces binding to the SH2 domain-containing protein 1A (SH2D1A) protein.

Participants:
(1) Docking protein 1 (DOK1)
(2) SH2 domain-containing protein 1A (SH2D1A)

Interactions
Interaction #1 DOK1 - SH2D1A

Interfaces
(1) ELM:LIG_SH2_IB motif (447ALYSQVQK454) in Docking protein 1 (DOK1)
(2) SH2 domain (4-87) in SH2 domain-containing protein 1A (SH2D1A)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y449 on Docking protein 1 (DOK1)) of the Docking protein 1 (DOK1) LIG_SH2_IB motif - SH2 domain-containing protein 1A (SH2D1A) SH2 domain interaction

References

(1) The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B.
Sylla et al. Proc. Natl. Acad. Sci. U.S.A. (2000)

See also

Other switches involving participants
Docking protein 1 (DOK1) - 4 more (view)
SH2 domain-containing protein 1A (SH2D1A) - 2 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IB - 13 more (view)


Loading visualisation

           
Please send any suggestions/comments to: switches@elm.eu.org