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Switch #:
Switch type:
Switch subtype:
Physicochemical compatibility

Phosphorylation of Y449 in the SH2-binding motif of Docking protein 1 (DOK1) induces binding to the SH2 domain-containing protein 1A (SH2D1A) protein.

(1) Docking protein 1 (DOK1)
(2) SH2 domain-containing protein 1A (SH2D1A)

Interaction #1 DOK1 - SH2D1A

(1) ELM:LIG_SH2_IB motif (447ALYSQVQK454) in Docking protein 1 (DOK1)
(2) SH2 domain (4-87) in SH2 domain-containing protein 1A (SH2D1A)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y449 on Docking protein 1 (DOK1)) of the Docking protein 1 (DOK1) LIG_SH2_IB motif - SH2 domain-containing protein 1A (SH2D1A) SH2 domain interaction


(1) The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B.
Sylla et al. Proc. Natl. Acad. Sci. U.S.A. (2000)

See also

Other switches involving participants
Docking protein 1 (DOK1) - 4 more (view)
SH2 domain-containing protein 1A (SH2D1A) - 2 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IB - 13 more (view)

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