Interaction #1 PTK2 - NCK2
(1) ELM:LIG_SH2_IA motif (389VSVSETDDYAEIIDEED405) in Focal adhesion kinase 1 (PTK2)
(2) SH2 domain (285-323) in Cytoplasmic protein NCK2 (NCK2)
PTM-dependent Induction (Phosphorylation of Y397 on Focal adhesion kinase 1 (PTK2)) of the Focal adhesion kinase 1 (PTK2) LIG_SH2_IA motif - Cytoplasmic protein NCK2 (NCK2) SH2 domain interaction
Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y397 : Tyrosine-protein kinase Fgr (FGR), Hepatocyte growth factor receptor (MET), Proto-oncogene tyrosine-protein kinase Src (SRC), Focal adhesion kinase 1 (PTK2).
(1) Nck-2 interacts with focal adhesion kinase and modulates cell motility.
Other switches involving participants