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Switch #:
SWTI000431
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y113 in the SH2-binding motif of Lymphocyte cytosolic protein 2 (LCP2) induces binding to the SH2 domain-containing adapter protein B (SHB) protein.

Participants:
(1) Lymphocyte cytosolic protein 2 (LCP2)
(2) SH2 domain-containing adapter protein B (SHB)

Interactions
Interaction #1 LCP2 - SHB

Interfaces
(1) ELM:LIG_SH2_IIB motif (105WSSFEEDDYESPND118) in Lymphocyte cytosolic protein 2 (LCP2)
(2) SH2 domain (410-485) in SH2 domain-containing adapter protein B (SHB)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y113 on Lymphocyte cytosolic protein 2 (LCP2)) of the Lymphocyte cytosolic protein 2 (LCP2) LIG_SH2_IIB motif - SH2 domain-containing adapter protein B (SHB) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y113 : Tyrosine-protein kinase Lck (LCK), Tyrosine-protein kinase SYK (SYK), Tyrosine-protein kinase ZAP-70 (ZAP70).

References

(1) Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells.
Lindholm et al. Eur. J. Biochem. (2002)

See also

Other switches involving participants
SH2 domain-containing adapter protein B (SHB) - 3 more (view)
Lymphocyte cytosolic protein 2 (LCP2) - 2 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIB - 12 more (view)


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