Switches.ELM

Switch #:

SWTI000442

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y20 in the SH2-binding motif of Dermcidin (DCD) induces binding to the Cytoplasmic protein NCK1 (NCK1) protein.

Participants:
(1) Dermcidin (DCD)
(2) Cytoplasmic protein NCK1 (NCK1)

Interactions

Interaction #1 DCD - NCK1

Interfaces
(1) ELM:LIG_SH2_IA motif (₁₅ALVCAYDPEAA₂₅) in Dermcidin (DCD)
(2) SH2 domain_(282-356) in Cytoplasmic protein NCK1 (NCK1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y₂₀ on Dermcidin (DCD)) of the Dermcidin (DCD) LIG_SH2_IA motif - Cytoplasmic protein NCK1 (NCK1) SH2 domain interaction

References

(1) Identification of Dermcidin as a novel binding protein of Nck1 and characterization of its role in promoting cell migration.
Shen et al. Biochim. Biophys. Acta (2011)