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Switch #:
SWTI000450
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1138 in the SH2-binding motif of Leptin receptor (Lepr) induces binding to the Signal transducer and activator of transcription 3 (STAT3) protein.

Participants:
(1) Leptin receptor (Lepr)
(2) Signal transducer and activator of transcription 3 (STAT3)

Interactions
Interaction #1 Lepr - STAT3

Interfaces
(1) ELM:LIG_SH2_III motif (1129GTSGENFVPYMPQFQTCSTH1148) in Leptin receptor (Lepr)
(2) SH2 domain (584-674) in Signal transducer and activator of transcription 3 (STAT3)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1138 on Leptin receptor (Lepr)) of the Leptin receptor (Lepr) LIG_SH2_III motif - Signal transducer and activator of transcription 3 (STAT3) SH2 domain interaction

References

(1) Activation of downstream signals by the long form of the leptin receptor.
Banks et al. J. Biol. Chem. (2000)

See also

Other switches involving participants
Signal transducer and activator of transcription 3 (STAT3) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_III - 15 more (view)


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