About Help Definitions Submit Search Analyse Browse Home


Switch #:
SWTI000451
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1328 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to the Tyrosine-protein kinase JAK1 (JAK1) protein.

Participants:
(1) Receptor tyrosine-protein kinase erbB-3 (ERBB3)
(2) Tyrosine-protein kinase JAK1 (JAK1)

Interactions
Interaction #1 ERBB3 - JAK1

Interfaces
(1) ELM:LIG_SH2_IE motif (1320DSAFDNPDYWHSRLFPK1336) in Receptor tyrosine-protein kinase erbB-3 (ERBB3)
(2) Tyrosine-protein kinase JAK1 (JAK1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1328 on Receptor tyrosine-protein kinase erbB-3 (ERBB3)) of the Receptor tyrosine-protein kinase erbB-3 (ERBB3) LIG_SH2_IE motif - Tyrosine-protein kinase JAK1 (JAK1) interaction

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane
Inferred: nucleus
References

(1) A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Jones et al. Nature (2006)

See also

Other switches involving participants
Receptor tyrosine-protein kinase erbB-3 (ERBB3) - 11 more (view)
Tyrosine-protein kinase JAK1 (JAK1) - 2 more (view)

Other switches involving interfaces
ELM:LIG_SH2_IE - 11 more (view)
IPR:IPR000980 - 9 more (view)


Loading visualisation

           
Please send any suggestions/comments to: switches@elm.eu.org