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Switch #:
SWTI000454
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1276 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to the Tyrosine-protein kinase JAK3 (JAK3) protein.

Participants:
(1) Receptor tyrosine-protein kinase erbB-3 (ERBB3)
(2) Tyrosine-protein kinase JAK3 (JAK3)

Interactions
Interaction #1 ERBB3 - JAK3

Interfaces
(1) ELM:LIG_SH2_IE motif (1268DGGGPGGDYAAMGACPA1284) in Receptor tyrosine-protein kinase erbB-3 (ERBB3)
(2) Tyrosine-protein kinase JAK3 (JAK3)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1276 on Receptor tyrosine-protein kinase erbB-3 (ERBB3)) of the Receptor tyrosine-protein kinase erbB-3 (ERBB3) LIG_SH2_IE motif - Tyrosine-protein kinase JAK3 (JAK3) interaction

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane
References

(1) A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Jones et al. Nature (2006)

See also

Other switches involving participants
Receptor tyrosine-protein kinase erbB-3 (ERBB3) - 11 more (view)

Other switches involving interfaces
ELM:LIG_SH2_IE - 11 more (view)
IPR:IPR000980 - 9 more (view)


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