Switch #: SWTI000455

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y713 in the SH2-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) protein.

Participants:
(1) Interleukin-4 receptor subunit alpha (IL4R)
(2) Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)

(1) Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation.
Kashiwada et al. J. Immunol. (2001)

Other switches involving participants
Interleukin-4 receptor subunit alpha (IL4R) - 7 more (view)
Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIA - 12 more (view)