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Physicochemical compatibility

Phosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.

(1) Cellular tumor antigen p53 (TP53)
(2) E3 ubiquitin-protein ligase Mdm2 (MDM2)


(1) Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding.
Sakaguchi et al. J. Biol. Chem. (2000)

(2) Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
Kussie et al. Science (1996)

See also

Other switches involving participants
Cellular tumor antigen p53 (TP53) - 10 more (view)
E3 ubiquitin-protein ligase Mdm2 (MDM2) - 3 more (view)

Other switches involving interfaces
DEG_MDM2_1 - 1 more (view)
SWIB/MDM2 domain - 1 more (view)

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