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Multisite phosphorylation of S737 and S739 in the SUMO-binding motif of Death domain-associated protein 6 (DAXX) by CK2 subfamily and CK2 subfamily increases the strength of the interaction with Small ubiquitin-related modifier 1 (SUMO1).

(1) Death domain-associated protein 6 (DAXX)
(2) Small ubiquitin-related modifier 1 (SUMO1)

Interaction #1 DAXX - SUMO1

(1) LIG_SUMO_SBM_1 motif (734IVLSDSD740) in Death domain-associated protein 6 (DAXX)
(2) Ubiquitin-2 like Rad60 SUMO-like (22-92) in Small ubiquitin-related modifier 1 (SUMO1)

Interaction Regulation
PTM-dependent Enhancement (Phosphorylation of S737 and S739 on Death domain-associated protein 6 (DAXX)) of the Death domain-associated protein 6 (DAXX) LIG_SUMO_SBM_1 motif - Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin-2 like Rad60 SUMO-like interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S737: CK2 subfamily; S739: CK2 subfamily

Additional Information
Affinity : Daxx(721-740): 55.3 (+/-14.2) µM, Daxx(721-740)-pS737: 4.6 (+/-1.2) µM, Daxx(721-740)-pS739: 2.8 (+/-0.3) µM, Daxx(721-740)-pS737-pS739: 1.6 (+/-0.4) µM
Structural information: 2KQS

(1) Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation.
Chang et al. Mol. Cell (2011)

See also

Other switches involving participants
Death domain-associated protein 6 (DAXX) - 5 more (view)
Small ubiquitin-related modifier 1 (SUMO1) - 6 more (view)

Other switches involving interfaces
LIG_SUMO_SBM_1 - 10 more (view)
Ubiquitin-2 like Rad60 SUMO-like - 10 more (view)

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