Switch #: SWTI000464

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the WW-binding motif of Angiomotin (AMOT), abrogating binding to WW domain-containing transcription regulator protein 1 (WWTR1). The splice specific Isoform p130 of Angiomotin (AMOT) of AMOT works within the Hippo pathway to sequester the transcription coactivator YAP1 away at tight junction. In contrast Isoform p80 of Angiomotin (AMOT) of AMOT lacks WW-binding motif.

Participants:
(1) Angiomotin (AMOT)
(2) WW domain-containing transcription regulator protein 1 (WWTR1)

(1) Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein.
Zhao et al. Genes Dev. (2011)

(2) Differential roles of p80- and p130-angiomotin in the switch between migration and stabilization of endothelial cells.
Ernkvist et al. Biochim. Biophys. Acta (2008)

Other switches involving participants
Angiomotin (AMOT) - 2 more (view)
WW domain-containing transcription regulator protein 1 (WWTR1) - 1 more (view)

Other switches involving interfaces
WW domain - 105 more (view)
LIG_WW_1 - 17 more (view)