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Switch #:
SWTI000465
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the PP2B-binding motif of Isoform 3 of Dynamin-1 (DNM1), abrogating binding to Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PPP3CA). This splice-specific motif in Isoform 3 of Dynamin-1 (DNM1) allows the docking of calcineurin phosphatase. The dephosphorylation of DNM1 by calcineurin, upon NGF stimulation, promotes the internalisation of the High affinity nerve growth factor receptor (NTRK1) (TrkA).

Participants:
(1) Isoform 3 of Dynamin-1 (DNM1)
(2) Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PPP3CA)

Interactions
Context
References

(1) Isoform-specific dephosphorylation of dynamin1 by calcineurin couples neurotrophin receptor endocytosis to axonal growth.
Bodmer et al. Neuron (2011)

See also

Other switches involving interfaces
Calcineurin-like phosphoesterase - 5 more (view)




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