Switch #: SWTI000466

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the PDZ-binding motif of Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22), abrogating binding to Disks large homolog 4 (DLG4). The motif-containing Isoform Epsilon of Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) forms part of a complex containing Leucine-rich glioma-inactivated protein 1 (LGI1), AMPA-R (e.g. Glutamate receptor 1 (GRIA1)) and AMPA-R regulatory proteins (e.g. Voltage-dependent calcium channel gamma-2 subunit (CACNG2)), and is closely associated with epilepsy.

Participants:
(1) Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22)
(2) Disks large homolog 4 (DLG4)

(1) Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission.
Fukata et al. Science (2006)

Other switches involving participants
Disks large homolog 4 (DLG4) - 7 more (view)
Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) - 1 more (view)

Other switches involving interfaces
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)