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Switch #:
SWTI000467
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the APC/C KEN-box degron motif of M-phase inducer phosphatase 2 (CDC25B), abrogating binding to Fizzy-related protein homolog (FZR1). The motif-lacking Isoform CDC25B2 of M-phase inducer phosphatase 2 (CDC25B) is not degraded during mitosis, unlike other isoforms.

Participants:
(1) M-phase inducer phosphatase 2 (CDC25B)
(2) Fizzy-related protein homolog (FZR1)

Interactions
Interaction #1 CDC25B - FZR1

Interfaces
(1) DEG_APCC_KENBOX_2 motif (191DKEND195) in M-phase inducer phosphatase 2 (CDC25B)
(2) WD domain, G-beta repeat (182-480) in Fizzy-related protein homolog (FZR1)

Interaction Regulation
Alternative splicing Abrogation of the M-phase inducer phosphatase 2 (CDC25B) DEG_APCC_KENBOX_2 motif - Fizzy-related protein homolog (FZR1) WD domain, G-beta repeat interaction

Additional Information
Switch_Notes: Suggested that this may favour inappropriate progression of cell through mitosis, thereby leading to genetic instability in cancer
Context
Switch localisation
Curated: cytosol
ELM curated: cytosol, nucleus
Inferred: nucleoplasm, cytosol

Switch cell cycle phase
Curated: mitosis

Switch pathways
Curated: Cell cycle
Inferred: Progesterone-mediated oocyte maturation
References

(1) Differential mitotic degradation of the CDC25B phosphatase variants.
Kieffer et al. Oncogene (2007)

See also

Other switches involving participants
M-phase inducer phosphatase 2 (CDC25B) - 2 more (view)

Other switches involving interfaces
WD domain, G-beta repeat - 36 more (view)
DEG_APCC_KENBOX_2 - 5 more (view)


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