Description: Alternative splicing removes the SH3-binding motif of Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15), abrogating binding to Proto-oncogene tyrosine-protein kinase Src (SRC). The overexpression of this splice variant has been linked to clinical aggressiveness of breast cancer.
Participants: (1) Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15) (2) Proto-oncogene tyrosine-protein kinase Src (SRC)
(1) Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer.Maretzky et al. Cancer Res. (2009)
Other switches involving participantsProto-oncogene tyrosine-protein kinase Src (SRC) - 2 more (view)Other switches involving interfacesLIG_SH3_2 - 5 more (view)SH3 domain - 7 more (view)
