Switch #: SWTI000490

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the WW-binding motif of Receptor tyrosine-protein kinase erbB-4 (ERBB4), abrogating binding to E3 ubiquitin-protein ligase Itchy homolog (ITCH). The presence of a WW-binding motif mediates ERBB4 mono-ubiquitination and endocytosis by the WW domain-containing HECT-type E3 ubiquitin ligase ITCH.

Participants:
(1) Receptor tyrosine-protein kinase erbB-4 (ERBB4)
(2) E3 ubiquitin-protein ligase Itchy homolog (ITCH)

(1) Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms.
Sundvall et al. Proc. Natl. Acad. Sci. U.S.A. (2008)

Other switches involving participants
Receptor tyrosine-protein kinase erbB-4 (ERBB4) - 4 more (view)
E3 ubiquitin-protein ligase Itchy homolog (ITCH) - 3 more (view)

Other switches involving interfaces
WW domain - 105 more (view)
LIG_WW_1 - 17 more (view)