Switch #: SWTI000491

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the myristoylation motif of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A). The soluble Isoform PDE2A1 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A) is expressed in a variety of peripheral tissues, whereas the membrane-associated Isoform PDE2A3 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A) is found exclusively in the brain. Isoform PDE2A3 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A) requires N-myristoylation together with palmitoylation to be targeted to synapses, allowing control and crosstalk of cyclic nucleotides.

Participants:
(1) cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A)
(2) Glycylpeptide N-tetradecanoyltransferase 1 (NMT1)

(1) Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes.
Russwurm et al. J. Biol. Chem. (2009)

Other switches involving interfaces
MOD_NMyristoyl - 2 more (view)