Switch #: SWTI000494

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the Dynein-binding motif of Bcl-2-like protein 11 (BCL2L11), abrogating binding to Dynein light chain 1, cytoplasmic (DYNLL1). Most BCL2L11 in healthy cells is sequestered away bound to DYNLL1 (the exception is Bim-S Isoform BCL2-like 11 transcript variant 9 of Bcl-2-like protein 11 (BCL2L11)). Cells exposed to environmental stress up-regulate c-Jun NH(2)-terminal kinases (JNK) that phosphorylate both BCL2L11 and BMF, releasing them from motor complexes and promoting apoptosis.

Participants:
(1) Bcl-2-like protein 11 (BCL2L11)
(2) Dynein light chain 1, cytoplasmic (DYNLL1)

(1) The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex.
Puthalakath et al. Mol. Cell (1999)

Other switches involving participants
Dynein light chain 1, cytoplasmic (DYNLL1) - 1 more (view)
Bcl-2-like protein 11 (BCL2L11) - 1 more (view)

Other switches involving interfaces
LIG_Dynein_DLC8_1 - 1 more (view)
Dynein light chain type 1 - 2 more (view)