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Switch #:
SWTI000496
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the EVH1-binding motif of Metabotropic glutamate receptor 1 (Grm1), abrogating binding to Homer protein homolog 1 (Homer1), which is important for spatial targeting of Grm1.

Participants:
(1) Metabotropic glutamate receptor 1 (Grm1)
(2) Homer protein homolog 1 (Homer1)

Interactions
Interaction #1 Grm1 - Homer1

Interfaces
(1) LIG_EVH1_2 motif (1152PPSPF1156) in Metabotropic glutamate receptor 1 (Grm1)
(2) WH1 domain (1-107) in Homer protein homolog 1 (Homer1)

Interaction Regulation
Alternative splicing Abrogation of the Metabotropic glutamate receptor 1 (Grm1) LIG_EVH1_2 motif - Homer protein homolog 1 (Homer1) WH1 domain interaction

Context
Switch localisation
ELM curated: cytosol, plasma membrane
Inferred: postsynaptic density, synaptosome


Switch pathways
Inferred: Glutamatergic synapse
References

(1) Homer: a protein that selectively binds metabotropic glutamate receptors.
Brakeman et al. Nature (1997)

See also

Other switches involving interfaces
WH1 domain - 2 more (view)


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