Switches.ELM

Switch #:

SWTI000510

Switch type:
Binary

Description:
Alternative splicing removes the 14-3-3-binding motif of Slowpoke-binding protein (Slob), abrogating binding to 14-3-3 family. Another 14-3-3 motif exists in this protein (50-RSNS-54) that is not altered by Alternative splicing. The removal of this motif therefore decreases the avidity of the interaction with 14-3-3 proteins.

Participants:
(1) Slowpoke-binding protein (Slob)
(2) 14-3-3 family

Interactions

Interaction #1 Slob - 14-3-3 family

Interfaces
(1) LIG_14-3-3_3 motif (₇₆RSASSE₈₁) in Slowpoke-binding protein (Slob)
(2) 14-3-3 protein_(-) in 14-3-3 family

Interaction Regulation
Alternative splicing Abrogation of the Slowpoke-binding protein (Slob) LIG_14-3-3_3 motif - 14-3-3 family 14-3-3 protein interaction

Context

Switch localisation
ELM curated: nucleus, cytosol, internal side of plasma membrane

References

(1) Expression and function of variants of slob, slowpoke channel binding protein, in Drosophila.
Jaramillo et al. J. Neurophysiol. (2006)