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Switch #:
SWTI000510
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the 14-3-3-binding motif of Slowpoke-binding protein (Slob), abrogating binding to 14-3-3 family. Another 14-3-3 motif exists in this protein (50-RSNS-54) that is not altered by Alternative splicing. The removal of this motif therefore decreases the avidity of the interaction with 14-3-3 proteins.

Participants:
(1) Slowpoke-binding protein (Slob)
(2) 14-3-3 family

Interactions
Interaction #1 Slob - 14-3-3 family

Interfaces
(1) LIG_14-3-3_3 motif (76RSASSE81) in Slowpoke-binding protein (Slob)
(2) 14-3-3 protein (-) in 14-3-3 family

Interaction Regulation
Alternative splicing Abrogation of the Slowpoke-binding protein (Slob) LIG_14-3-3_3 motif - 14-3-3 family 14-3-3 protein interaction

Context
References

(1) Expression and function of variants of slob, slowpoke channel binding protein, in Drosophila.
Jaramillo et al. J. Neurophysiol. (2006)

See also

Other switches involving participants
Slowpoke-binding protein (Slob) - 1 more (view)

Other switches involving interfaces
LIG_14-3-3_3 - 16 more (view)
14-3-3 protein - 38 more (view)




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