Switches.ELM

Switch #:

SWTI000511

Switch type:
Binary

Description:
Alternative promoter usage removes the RPEL-binding motif of Myocardin (Myocd), abrogating binding to Actin, alpha skeletal muscle (Acta1). 3 RPEL motifs are found in Myocd. The shortened form lacks 2 RPEL motifs but no definitive comparison of binding to actin has been undertaken between isoforms.

Participants:
(1) Myocardin (Myocd)
(2) Actin, alpha skeletal muscle (Acta1)

Interactions

Interaction #1 Myocd - Acta1

Interfaces
(1) LIG_Actin_RPEL_3 motif (₂₀LQLRLQQRRTQEQLANQGLI₃₉) in Myocardin (Myocd)
(2) Actin_(4-377) in Actin, alpha skeletal muscle (Acta1)

Interaction Regulation
Alternative promoter usage Abrogation of the Myocardin (Myocd) LIG_Actin_RPEL_3 motif - Actin, alpha skeletal muscle (Acta1) Actin interaction

Context

Switch localisation
ELM curated: cytosol

References

(1) Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR.
Creemers et al. Mol. Cell (2006)