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Switch #:
SWTI000511
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative promoter usage removes the RPEL-binding motif of Myocardin (Myocd), abrogating binding to Actin, alpha skeletal muscle (Acta1). 3 RPEL motifs are found in Myocd. The shortened form lacks 2 RPEL motifs but no definitive comparison of binding to actin has been undertaken between isoforms.

Participants:
(1) Myocardin (Myocd)
(2) Actin, alpha skeletal muscle (Acta1)

Interactions
Interaction #1 Myocd - Acta1

Interfaces
(1) LIG_Actin_RPEL_3 motif (20LQLRLQQRRTQEQLANQGLI39) in Myocardin (Myocd)
(2) Actin (4-377) in Actin, alpha skeletal muscle (Acta1)

Interaction Regulation
Alternative promoter usage Abrogation of the Myocardin (Myocd) LIG_Actin_RPEL_3 motif - Actin, alpha skeletal muscle (Acta1) Actin interaction

Context
Switch localisation
ELM curated: cytosol
References

(1) Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR.
Creemers et al. Mol. Cell (2006)

See also

Other switches involving participants
Actin, alpha skeletal muscle (Acta1) - 2 more (view)
Myocardin (Myocd) - 1 more (view)

Other switches involving interfaces
LIG_Actin_RPEL_3 - 2 more (view)
Actin - 3 more (view)




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