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Alternative splicing removes the PP1-binding motif of A-kinase anchor protein 1, mitochondrial (AKAP1), abrogating binding to PP-1 subfamily. Isoform AKAP149 of A-kinase anchor protein 1, mitochondrial (AKAP1) may conceivably position PKA and PP1 in close proximity where they can reversibly modulate the phosphorylation of nuclear substrates such as NPP1, DNA-binding cAMP response elements, B-type lamins and inner nuclear membrane proteins LBR and lamina-associated polypeptides, which all harbor PKA phosphorylation sites.

(1) A-kinase anchor protein 1, mitochondrial (AKAP1)
(2) PP-1 subfamily

Interaction #1 AKAP1 - PP-1 subfamily

(1) DOC_PP1 motif (151SPKGVLFS158) in A-kinase anchor protein 1, mitochondrial (AKAP1)
(2) Calcineurin-like phosphoesterase (-) in PP-1 subfamily

Interaction Regulation
Alternative splicing Abrogation of the A-kinase anchor protein 1, mitochondrial (AKAP1) DOC_PP1 motif - PP-1 subfamily Calcineurin-like phosphoesterase interaction


(1) Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly.
Steen et al. J. Cell Biol. (2000)

See also

Other switches involving interfaces
DOC_PP1 - 4 more (view)
Calcineurin-like phosphoesterase - 5 more (view)

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