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Switch #:
SWTI000523
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative promoter usage removes the mitochondrial localisation signal (MLS) of Isoform UNG1 of Uracil-DNA glycosylase (UNG), abrogating binding to Mitochondrial import receptor subunit TOM70 (TOMM70A) and import into mitochondria. In Isoform UNG2 of Uracil-DNA glycosylase (UNG) the MLS present in Isoform UNG1 of Uracil-DNA glycosylase (UNG) is replaced with a nuclear localisation signal (NLS), promoting different localisations of the different protein isoforms.

Participants:
(1) Isoform UNG1 of Uracil-DNA glycosylase (UNG)
(2) Mitochondrial import receptor subunit TOM70 (TOMM70A)

Interactions
Interaction #1 UNG - TOMM70A

Interfaces
(1) ELM:TRG_MLS motif (1MGVFCLGPWGLGRKLRTPGKGPLQLLSRLCGDHLQAIPAKKAPA44) in Isoform UNG1 of Uracil-DNA glycosylase (UNG)
(2) Tetratricopeptide repeat (114-578) in Mitochondrial import receptor subunit TOM70 (TOMM70A)

Interaction Regulation
Alternative promoter usage Abrogation of the Isoform UNG1 of Uracil-DNA glycosylase (UNG) TRG_MLS motif - Mitochondrial import receptor subunit TOM70 (TOMM70A) Tetratricopeptide repeat interaction

References

(1) Identification of sequence determinants of human nuclear dUTPase isoform localization.
Tinkelenberg et al. Exp. Cell Res. (2003)

See also

Other switches involving participants
Mitochondrial import receptor subunit TOM70 (TOMM70A) - 7 more (view)

Other switches involving interfaces
ELM:TRG_MLS - 7 more (view)
Tetratricopeptide repeat - 8 more (view)


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