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Switch #:
SWTI000524
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing partially removes the IQ motif of Isoform CI of Plasma membrane calcium-transporting ATPase 1 (ATP2B1), partially inhibiting binding to Calmodulin (CALM1).

Participants:
(1) Isoform CI of Plasma membrane calcium-transporting ATPase 1 (ATP2B1)
(2) Calmodulin (CALM1)

Interactions
Interaction #1 ATP2B1 - CALM1

Interfaces
(1) ELM:LIG_IQ_2 motif (1114IQTQIRVVNAFRSSL1128) in Isoform CI of Plasma membrane calcium-transporting ATPase 1 (ATP2B1)
(2) EF-hand domain pair (8-73) in Calmodulin (CALM1)

Interaction Regulation
Alternative splicing Inhibition of the Isoform CI of Plasma membrane calcium-transporting ATPase 1 (ATP2B1) LIG_IQ_2 motif - Calmodulin (CALM1) EF-hand domain pair interaction

Context
References

(1) Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.
Strehler et al. Physiol. Rev. (2001)

See also

Other switches involving participants
Isoform CI of Plasma membrane calcium-transporting ATPase 1 (ATP2B1) - 1 more (view)
Calmodulin (CALM1) - 1 more (view)

Other switches involving interfaces
EF-hand domain pair - 5 more (view)
ELM:LIG_IQ_2 - 1 more (view)




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